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Sickle cell disease is a group of blood disorders inherited from both parents, causing abnormal red blood cells that can lead to pain, anemia, infections, and organ damage. Learn about the symptoms, diagnosis, treatment, and prevention of sickle cell disease and its subtypes.
Sickle cell trait is a condition where a person has one abnormal allele of the hemoglobin beta gene (genotype AS) and produces both normal and abnormal hemoglobin. It is associated with some resistance to malaria, but also rare complications such as sickle cell crisis, renal medullary carcinoma, and urinary tract infection.
Learn how inherited changes in DNA increase resistance to malaria and result in blood disorders. Find out how malaria exerts evolutionary pressure on human genome and how it affects red blood cells.
Learn about human traits that are influenced by Mendelian inheritance, such as albinism, sickle-cell disease, and lactase persistence. Find out the patterns of inheritance, examples, and non-Mendelian traits.
Learn about the genetic differences and similarities among human populations, the causes and measures of variation, and the evolutionary and medical implications. Explore the topics of chromosome abnormalities, nucleotide diversity, single nucleotide polymorphisms, and more.
Learn about the formation, ethnogenesis, and DNA-specific information of populations in Europe. Explore the prehistoric and historical population movements, admixtures, and genetic structure of Europeans.
A South African geneticist and medical scientist who discovered the genetic resistance to malaria and developed CellCept. He worked at Oxford, London, Nairobi, and California, and published over 400 papers and 12 books.
Some of the genetic disorders endemic to the Arab world are: hemoglobinopathy, sickle cell anemia, glucose-6-phosphate dehydrogenase deficiency, and fragile X syndrome (FXS), which is an inherited genetic condition with critical consequences. The Centre provide information about specific countries, [46] and maintain a list of Genomic diseases.