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Sickle cell disease is a group of blood disorders inherited from both parents, causing abnormal red blood cells that can lead to pain, anemia, infections, and organ damage. Learn about the symptoms, diagnosis, treatment, and prevention of sickle cell disease and its subtypes.
Sickle cell trait is a condition where a person has one abnormal allele of the hemoglobin beta gene (genotype AS) and produces both normal and abnormal hemoglobin. It is associated with some resistance to malaria, but also rare complications such as sickle cell crisis, renal medullary carcinoma, and urinary tract infection.
Lyfgenia is a brand name for lovotibeglogene autotemcel, a lentiviral gene therapy that modifies blood stem cells to produce a hemoglobin variant that reduces sickling. The FDA approved Lyfgenia in December 2023 for people with sickle cell disease and a history of vaso-occlusive events.
The US Food and Drug Administration on Friday approved two gene-based treatments for sickle cell disease, including the first therapy that uses the gene-editing technique CRISPR, opening a new era ...
“The use of the word ‘cure’ in relation to sickle cell disease or thalassemia has, up until now, been incompatible,” she said in a statement, calling the MHRA's approval of gene therapy ...
The Food and Drug Administration must decide by Friday whether to approve a new gene-editing therapy to treat sickle cell disease, a debilitating blood disorder that affects at least 100,000 ...
The Duffy antigen is a protein on red blood cells that is a receptor for some chemokines and malarial parasites. It is part of the Duffy blood group system, which has six phenotypes and five antigens, and is influenced by a single gene on chromosome 1.
This 2019 image provided by the Sarah Cannon Research Institute shows Victoria Gray of Mississippi on her infusion day during a gene editing trial for sickle cell disease at the Sarah Cannon ...