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Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. The most common type is known as sickle cell anemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells.
Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood.
Sickle cell anemia; Hemoglobinopathies causing unstable hemoglobins; Paroxysmal nocturnal hemoglobinuria; Extrinsic (extracorpuscular) abnormalities Antibody-mediated Warm autoimmune hemolytic anemia is caused by autoimmune attack against red blood cells, primarily by IgG. It is the most common of the autoimmune hemolytic diseases.
Sickle cell anemia: 11p15: P Siderius X-linked mental retardation syndrome: PHF8: X-Linked Recessive Sideroblastic anemia: ABCB7, SLC25A38, GLRX5: recessive Sly syndrome: GUSB: recessive 1:250,000 Smith–Lemli–Opitz syndrome: DHCR7: recessive 1:20,000-60,000 Smith–Magenis syndrome: 17p11.2 dominant 1:15,000-25,000 Snyder–Robinson ...
Linus Carl Pauling FRS ( / ˈpɔːlɪŋ / PAW-ling; February 28, 1901 – August 19, 1994) [4] was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. [5] New Scientist called him one of the 20 greatest ...
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For people living with the disease, a sickle cell crisis can happen at any time. When it does, their rigid, sickle-shaped red blood cells become stuck in their blood vessels, blocking flow and ...
Parvovirus B19 is a cause of chronic anemia in individuals with immunodeficiency, receiving immunosuppressive therapy or with HIV infection. Treatment with intravenous immunoglobulin usually resolves the anemia although relapse can occur.
Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous), but does not display the severe symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous).
Sickle-cell disease. Myocardial infarction. Scientific career. Fields. Medicine. James Bryan Herrick (11 August 1861 in Oak Park, Illinois – 7 March 1954 in Chicago, Illinois) was an American physician and professor of medicine who practiced and taught in Chicago. He is credited with the description of sickle-cell disease and was one of the ...