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  2. Sickle cell disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_disease

    Long-term pain may develop as people get older. [2] The average life expectancy in the developed world is 40 to 60 years. It often gets worse within age. [10] All the major organs are affected by sickle cell disease.

  3. Acute chest syndrome - Wikipedia

    en.wikipedia.org/wiki/Acute_chest_syndrome

    The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell anemia. This condition commonly manifests with a new opacification of the lung (s) on a chest x-ray. [1]

  4. Autoimmune hemolytic anemia - Wikipedia

    en.wikipedia.org/wiki/Autoimmune_hemolytic_anemia

    A hemolytic state exists whenever the red cell survival time is shortened from the normal average of 120 days. Hemolytic anemia is the hemolytic state in which anemia is present, and bone marrow function is inferentially unable to compensate for the shortened lifespan of the red cell.

  5. Sickle cell gene therapy not approved for widespread NHS use ...

    www.aol.com/sickle-cell-gene-therapy-not...

    A world-first gene therapy for severe sickle cell disease has not been approved for widespread NHS use in new draft guidance.

  6. Sickle cell trait - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_trait

    Sickle-cell disease and the associated trait are most prevalent in Africa and Central America, which is attributed to natural selection: the sickle-cell trait confers a survival advantage in areas with a high occurrence of malaria, which has a high death rate among individuals without the trait. [citation needed]

  7. Vaso-occlusive crisis - Wikipedia

    en.wikipedia.org/wiki/Vaso-occlusive_crisis

    Neuropathic pain, hyperalgesia, osteomyelitis. A vaso-occlusive crisis is a common painful complication of sickle cell anemia in adolescents and adults. [1] [2] It is a form of sickle cell crisis.

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