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  2. Asplenia - Wikipedia

    en.wikipedia.org/wiki/Asplenia

    After splenectomy with the goal of arresting the progression of cancers (Chronic lymphocytic leukemia, Hodgkin's disease (starting in the 1970s), non-Hodgkin lymphoma) Due to underlying diseases that destroy the spleen (autosplenectomy), e.g. sickle-cell disease. Celiac disease: unknown physiopathology.

  3. Dyskeratosis congenita - Wikipedia

    en.wikipedia.org/wiki/Dyskeratosis_congenita

    Dyskeratosis congenita ( DKC ), also known as Zinsser-Engman-Cole syndrome, is a rare progressive congenital disorder with a highly variable phenotype. [3] The entity was classically defined by the triad of abnormal skin pigmentation, nail dystrophy, and leukoplakia of the oral mucosa, and MDS/AML, but these components do not always occur. [3 ...

  4. Spinal muscular atrophy - Wikipedia

    en.wikipedia.org/wiki/Spinal_muscular_atrophy

    1 in 10,000 people [2] Spinal muscular atrophy ( SMA) is a rare neuromuscular disorder that results in the loss of motor neurons and progressive muscle wasting. [3] [4] [5] It is usually diagnosed in infancy or early childhood and if left untreated it is the most common genetic cause of infant death. [6] It may also appear later in life and ...

  5. Race and health in the United States - Wikipedia

    en.wikipedia.org/wiki/Race_and_health_in_the...

    Life expectancy. The twentieth century witnessed a great expansion of the upper bounds of the human life span. At the beginning of the century, average life expectancy in the United States was 47 years. By the century's end, the average life expectancy had risen to over 70 years, and it was not unusual for Americans to exceed 80 years of age.

  6. Balancing selection - Wikipedia

    en.wikipedia.org/wiki/Balancing_selection

    In such individuals, the hemoglobin in red blood cells is extremely sensitive to oxygen deprivation, which results in shorter life expectancy. A person who inherits the sickle cell gene from one parent and a normal hemoglobin allele (HgbA) from the other, has a normal life expectancy. However, these heterozygote individuals, known as carriers ...

  7. Global Burden of Disease Study - Wikipedia

    en.wikipedia.org/wiki/Global_Burden_of_Disease_Study

    The Global Burden of Disease Study began in 1990 as a single World Bank -commissioned [3] study that quantified the health effects of more than 100 diseases and injuries for eight regions of the world, giving estimates of morbidity and mortality by age, sex, and region. It also introduced the disability-adjusted life year (DALY) as a new metric ...

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