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Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. [2] The most common type is known as sickle cell anemia. [2] It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2] This leads to a rigid, sickle -like shape under ...
CRISPR gene editing (CRISPR, pronounced / ˈkrɪspər / "crisper", refers to " c lustered r egularly i nterspaced s hort p alindromic r epeats") is a genetic engineering technique in molecular biology by which the genomes of living organisms may be modified.
Anemia or anaemia (British English) is a blood disorder in which the blood has a reduced ability to carry oxygen. This can be due to a lower than normal number of red blood cells, a reduction in the amount of hemoglobin available for oxygen transport, or abnormalities in hemoglobin that impair its function. [3][4]
However, the level of Hb F can be elevated in persons with sickle-cell disease and beta-thalassemia. Gene expression of hemoglobin before and after birth. Also identifies the types of cells and organs in which the gene expression (data on Wood W.G., (1976). Br. Med. Bull. 32, 282.) Abnormal forms that occur in diseases:
For example, sickle-cell anemia is a human genetic disease that results from a single base difference within the coding region for the β-globin section of hemoglobin, causing a single amino acid change that changes hemoglobin's physical properties. [78]
However, the overall contribution of vitamin B 12 deficiency to the global incidence of anemia may not be significant, except in elderly individuals, vegetarians, cases of malabsorption and some genetic disorders. [87] Anemia is defined as a condition in which there are not enough red blood cells, as the tissues and organs of the body do not ...