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Two antibodies can have the same affinity, but one may have both a high on- and off-rate constant, while the other may have both a low on- and off-rate constant. K A = k forward k back = on-rate off-rate {\displaystyle K_{A}={\frac {k_{\text{forward}}}{k_{\text{back}}}}={\frac {\mbox{on-rate}}{\mbox{off-rate}}}}
To calculate a percentage of a percentage, convert both percentages to fractions of 100, or to decimals, and multiply them. For example, 50% of 40% is: 50 / 100 × 40 / 100 = 0.50 × 0.40 = 0.20 = 20 / 100 = 20%.
The binding constant, or affinity constant/association constant, is a special case of the equilibrium constant K, and is the inverse of the dissociation constant. It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as: R + L ⇌ RL. The reaction is characterized by the on-rate ...
In computing, a roundoff error, [1] also called rounding error, [2] is the difference between the result produced by a given algorithm using exact arithmetic and the result produced by the same algorithm using finite-precision, rounded arithmetic. [3]
Multiply that figure by the initial balance of your loan, which should start at the full amount you borrowed. For the figures above, the loan payment formula would look like: 0.06 divided by 12 ...
Exponential decay is a scalar multiple of the exponential distribution (i.e. the individual lifetime of each object is exponentially distributed), which has a well-known expected value. We can compute it here using integration by parts .
The runoff curve number was developed from an empirical analysis of runoff from small catchments and hillslope plots monitored by the USDA. It is widely used and is an efficient method for determining the approximate amount of direct runoff from a rainfall event in a particular area.
Sensitivity (true positive rate) is the probability of a positive test result, conditioned on the individual truly being positive. Specificity (true negative rate) is the probability of a negative test result, conditioned on the individual truly being negative. If the true status of the condition cannot be known, sensitivity and specificity can ...
Peak demand on an electrical grid is the highest electrical power demand that has occurred over a specified time period (Gönen 2008). Peak demand is typically characterized as annual, daily or seasonal and has the unit of power. [1] Peak demand, peak load or on-peak are terms used in energy demand management describing a period in which ...
In decision theory, the expected value of perfect information ( EVPI) is the price that one would be willing to pay in order to gain access to perfect information. [1] A common discipline that uses the EVPI concept is health economics. In that context and when looking at a decision of whether to adopt a new treatment technology, there is always ...