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Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. The most common type is known as sickle cell anemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells.
In 1954 he discovered, confirming his preconception, that people with sickle-cell trait are resistant to the deadly falciparum malaria. In the 1970s, Allison had worked out the enzyme, inosine monophosphate dehydrogenase , as a key molecule of the immune response in autoimmune diseases and in organ transplantation .
The Sickle Cell Disease Association of America, Inc. (SCDAA) is a nonprofit organization with the sole purpose of supporting research, education and funding of individuals, families those who are impacted by sickle cell disease.
Download as PDF. Printable version. From Wikipedia, the free encyclopedia. Redirect page. Redirect to: Sickle cell disease. Retrieved from "https://en.wikipedia.org/w/index.php?title=World_Sickle_Cell_Day&oldid=845659330". This page was last edited on 13 June 2018, at 08:25 (UTC). Text is available under the Creative Commons Attribution ...
His first discovery, in 1910, was that of sickle-shaped red blood cells on the blood film of a dental student from Grenada. His description of the student's disease was known for many years as Herrick's syndrome , and is now known as sickle-cell disease .
Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous), but does not display the severe symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous).
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CHORI is the first research institute in North America to transplant and cure a child with alpha thalassemia major, [citation needed] is a leading center for the use of cord blood and bone marrow transplantation in children with sickle cell anemia and thalassemia, and offers the only not-for-profit Sibling Donor Cord Blood Program in the world.
Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease (HbS) that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three variants described in association with HbS.
Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood.
