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Amphetamine is a weak base with a pK a of 9.9; [20] consequently, when the pH is basic, more of the drug is in its lipid soluble free base form, and more is absorbed through the lipid-rich cell membranes of the gut epithelium. [20] [87] Conversely, an acidic pH means the drug is predominantly in a water-soluble cationic (salt) form, and less is ...
Highway 407 begins at the Highway 403/Queen Elizabeth Way junction in Burlington. Highway 407 is a 151.4-kilometre (94.1 mi) [1] controlled-access highway that encircles the GTA, passing through Burlington, Oakville, Mississauga, Brampton, Vaughan, Markham, Pickering, Whitby, Oshawa, and Clarington, as well as travelling immediately north of Toronto.