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2. Sickle cell disease - Wikipedia

   en.wikipedia.org/wiki/Sickle_cell_disease

   Signs of sickle cell disease usually begin in early childhood. The severity of symptoms can vary from person to person, as can the frequency of crisis events. [20] [16] Sickle cell disease may lead to various acute and chronic complications, several of which have a high mortality rate. [21]

3. Thalassemia - Wikipedia

   en.wikipedia.org/wiki/Thalassemia

   Males and females have similar rates of disease. [ citation needed ] It resulted in 16,800 deaths in 2015, down from 36,000 deaths in 1990. [ 6 ] [ 15 ] Those who have minor degrees of thalassemia, in common with those who have sickle-cell trait , have some protection against malaria , explaining why sickle-cell trait and thalassemia are more ...

4. Splenic sequestration crisis - Wikipedia

   en.wikipedia.org/wiki/Splenic_sequestration_crisis

   Splenic sequestration crisis is a life-threatening illness common in pediatric patients with homozygous sickle cell disease and beta thalassemia. Up to 30% of these children may develop splenic sequestration crisis with a mortality rate of up to 15%. This crisis occurs when splenic vaso-occlusion causes a large percentage of total blood volume ...

5. FDA approves cure for sickle cell disease, the first ... - AOL

   www.aol.com/news/fda-approves-cure-sickle-cell...

   December 8, 2023 at 1:19 PM. The Food and Drug Administration on Friday approved a powerful treatment for sickle cell disease, a devastating illness that affects more than 100,000 Americans, the ...

6. For people with sickle cell disease, ERs can mean life ... - AOL

   www.aol.com/news/people-sickle-cell-disease-ers...

   For people living with the disease, a sickle cell crisis can happen at any time. When it does, their rigid, sickle-shaped red blood cells become stuck in their blood vessels, blocking flow and ...

7. Acute chest syndrome - Wikipedia

   en.wikipedia.org/wiki/Acute_chest_syndrome

   Both may present with a new opacification of the lung on chest x-ray. The presence of fevers, low oxygen levels in the blood, increased respiratory rate, chest pain, and cough are also common in acute chest syndrome. Diagnostic workup includes chest x-ray, complete cell count, reticulocyte count, ECG, and blood and sputum cultures.