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Molar mass. 146 232.04 g·mol −1. Crizanlizumab, sold under the brand name Adakveo among others, is a monoclonal antibody medication that binds to P-selectin. [3] It is a medication used to reduce the frequency of vaso-occlusive crisis in people aged 16 years and older who have sickle cell anemia. [3] [4] [6] It is given by injection into a vein.
The following is a list of the 67 counties of the U.S. state of Pennsylvania. The city of Philadelphia is coterminous with Philadelphia County, the municipalities having been consolidated in 1854, and all remaining county government functions having been merged into the city after a 1951 referendum. [1] [2] Eight of the ten most populous ...
Hemoglobin C (abbreviated as HbC) is an abnormal hemoglobin in which glutamic acid residue at the 6th position of the β-globin chain is replaced with a lysine residue due to a point mutation in the HBB gene. [1] People with one copy of the gene for hemoglobin C do not experience symptoms, but can pass the abnormal gene on to their children.
The Pennsylvania Portal. Pennsylvania ( / ˌpɛnsɪlˈveɪniə / ⓘ, lit. 'Penn's forest country' ), officially the Commonwealth of Pennsylvania ( Pennsylvania Dutch: Pennsylvanie ), is a state spanning the Mid-Atlantic, Northeastern, Appalachian, and Great Lakes regions of the United States. Pennsylvania borders Delaware to its southeast ...
U.S. Route 219, a four-lane highway, crosses the township from north to south, with access from an interchange with Pennsylvania Route 53 just south of Ehrenfeld. According to the United States Census Bureau , the township has a total area of 18.36 square miles (47.55 km 2 ), of which 18.33 square miles (47.47 km 2 ) is land and 0.03 square ...
Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease (HbS) that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three variants described in association with HbS.
UTC-5 ( EST) • Summer ( DST) UTC-4 ( EDT) Area code (s) 610. Earl Township is a township in Berks County, Pennsylvania, United States. The population was 3,102 at the 2020 census. [2] Earl Township was named for early German settler Hans Graaf. His surname Graaf means "earl" in English.
Mendelian traits in humans. A 50/50 chance of inheritance. Sickle-cell disease is inherited in the autosomal recessive pattern. When both parents have sickle-cell trait (carrier), a child has a 25% chance of sickle-cell disease (red icon), 25% do not carry any sickle-cell alleles (blue icon), and 50% have the heterozygous (carrier) condition. [1]
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