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She is a consultant pediatrician and professor of pediatrics who majored in Neonatology under the University of Benin Teaching Hospital (1972-till date). In this institution, she indulges in both teaching and researching on neonatology and perinatal health. She lectures at various institutes one of which is Delta State University.
Osteonecrosis is also associated with cancer, lupus, sickle cell disease, HIV infection, Gaucher's disease, and Caisson disease (dysbaric osteonecrosis). Bisphosphonates are associated with osteonecrosis of the mandible (jawbone). The condition may also occur without any clear reason.
Autosplenectomy can occur in cases of sickle-cell disease where the misshapen cells block blood flow to the spleen, causing scarring and eventual atrophy of the organ. Autosplenectomy is a rare condition that is linked to certain diseases but is not a common occurrence. It is also seen in systemic lupus erythematosus (SLE).
Category:Deaths from sickle-cell disease. Category. : Deaths from sickle-cell disease. This is a non-diffusing subcategory of Category:People with sickle-cell disease. It includes People with sickle-cell disease that can also be found in the parent category, or in diffusing subcategories of the parent.
Photomicrograph of normal-shaped and sickle-shape red blood cells from a patient with sickle cell disease. Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal flexible, round shape. It is caused by a change in one nucleotide, a point mutation in the HBB gene.
The human disease sickle cell anemia is caused by a genetic mutation in the codon for the sixth amino acid of the blood protein beta-hemoglobin.The normal DNA sequence G-A-G codes for the amino acid glutamate, while the mutation changes the middle adenine to a thymine, leading to the sequence G-T-G (G-U-G in the mRNA).
Dacrocytes compared to other forms of poikilocytosis. A dacrocyte (or dacryocyte) is a type of poikilocyte that is shaped like a teardrop (a "teardrop cell"). A marked increase of dacrocytes is known as dacrocytosis. These tear drop cells are found primarily in diseases with bone marrow fibrosis, such as: primary myelofibrosis, myelodysplastic ...
With HbS, there can be mild sickle cell trait but no symptoms. Hemoglobin O-Arab causes sickle cell disease in heterozygous (HbS/HbO) individuals. However, the symptomatic anemia is mild and is not life-threatening. It is even milder than in heterozygous sickle cell trait (HbS/HbA). A case of sickle cell retinopathy is documented.
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