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  2. Sickle cell disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_disease

    Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. The most common type is known as sickle cell anemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells.

  3. Sickle cell trait - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_trait

    Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous), but does not display the severe symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous).

  4. Vaso-occlusive crisis - Wikipedia

    en.wikipedia.org/wiki/Vaso-occlusive_crisis

    Symptoms: acute, severe pain: Diagnostic method: There is no test to confirm a vaso-occlusive crisis, but tests can be done to rule out other causes. Patients with vaso-occlusive crisis present with pain (mild to severe) and a history of sickle cell anemia. Differential diagnosis: Neuropathic pain, hyperalgesia, osteomyelitis

  5. New sickle cell treatment sparks feelings of hope and some ...

    www.aol.com/sickle-cell-treatment-sparks...

    The main symptoms of sickle cell disease are disruptive to people’s “quality of life and ability to just function as normal humans,” she said. Kayla Smith Owens on her 25th receiving ...

  6. Acute chest syndrome - Wikipedia

    en.wikipedia.org/wiki/Acute_chest_syndrome

    Signs and symptoms. The crisis is a common complication in sickle-cell patients and can be associated with one or more symptoms including fever, cough, excruciating pain, sputum production, shortness of breath, or low oxygen levels. [2]

  7. Hemoglobin Lepore syndrome - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome

    Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease (HbS) that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three variants described in association with HbS.

  8. Sickle cell retinopathy - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_retinopathy

    Anterior segment signs including the conjunctival sign and iris atrophy are ocular manifestations that are strongly indicative of sickle cell disease. Early stages of sickle cell retinopathy are asymptomatic.

  9. Sickle cell nephropathy - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_nephropathy

    Signs and Symptoms. Microalbuminuria is an early sign of SCN that has a 30-60% of developing in those with sickle cell disease (SCD). Hematuria can appear in a range of severities from painless and minute to excessive and painful.

  10. Hemoglobin C - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_C

    It is possible for a person to have both the gene for hemoglobin S (the form associated with sickle cell anemia) and the gene for hemoglobin C; this state is called hemoglobin SC disease, and is generally more severe than hemoglobin C disease, but milder than sickle cell anemia.

  11. Autosplenectomy - Wikipedia

    en.wikipedia.org/wiki/Autosplenectomy

    Autosplenectomy can occur in cases of sickle-cell disease where the misshapen cells block blood flow to the spleen, causing scarring and eventual atrophy of the organ. Autosplenectomy is a rare condition that is linked to certain diseases but is not a common occurrence.