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  2. Sickle cell disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_disease

    Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. [2] The most common type is known as sickle cell anemia. [2] It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2] This leads to a rigid, sickle -like shape under ...

  3. Malaria - Wikipedia

    en.wikipedia.org/wiki/Malaria

    Sickle cell trait causes a change in the haemoglobin molecule in the blood. Normally, red blood cells have a very flexible, biconcave shape that allows them to move through narrow capillaries ; however, when the modified haemoglobin S molecules are exposed to low amounts of oxygen, or crowd together due to dehydration, they can stick together ...

  4. Mutation - Wikipedia

    en.wikipedia.org/wiki/Mutation

    For other uses, see Mutation (disambiguation). Three major single-chromosome mutations: deletion (1), duplication (2) and inversion (3). In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. [ 1 ] Viral genomes contain either DNA or RNA.

  5. Plasmodium falciparum - Wikipedia

    en.wikipedia.org/wiki/Plasmodium_falciparum

    Haemosporidium vigesimotertianaeLewkowicz, 1897. Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans. [ 2 ] The parasite is transmitted through the bite of a female Anopheles mosquito and causes the disease's most dangerous form, falciparum malaria.

  6. Anemia - Wikipedia

    en.wikipedia.org/wiki/Anemia

    Anemia or anaemia (British English) is a blood disorder in which the blood has a reduced ability to carry oxygen. This can be due to a lower than normal number of red blood cells, a reduction in the amount of hemoglobin available for oxygen transport, or abnormalities in hemoglobin that impair its function. [3][4]

  7. Hemoglobin - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin

    However, the level of Hb F can be elevated in persons with sickle-cell disease and beta-thalassemia. Gene expression of hemoglobin before and after birth. Also identifies the types of cells and organs in which the gene expression (data on Wood W.G., (1976). Br. Med. Bull. 32, 282.) Abnormal forms that occur in diseases:

  8. CRISPR gene editing - Wikipedia

    en.wikipedia.org/wiki/CRISPR_gene_editing

    CRISPR gene editing (CRISPR, pronounced / ˈkrɪspər / "crisper", refers to " c lustered r egularly i nterspaced s hort p alindromic r epeats") is a genetic engineering technique in molecular biology by which the genomes of living organisms may be modified.

  9. Prion - Wikipedia

    en.wikipedia.org/wiki/Prion

    A prion / ˈpriːɒn / ⓘ is a misfolded protein that induces misfolding in normal variants of the same protein, leading to cellular death. Prions are responsible for prion diseases, known as transmissible spongiform encephalopathies (TSEs), which are fatal and transmissible neurodegenerative diseases affecting both humans and animals. [ 3 ...