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Sickle cell trait causes a change in the haemoglobin molecule in the blood. Normally, red blood cells have a very flexible, biconcave shape that allows them to move through narrow capillaries ; however, when the modified haemoglobin S molecules are exposed to low amounts of oxygen, or crowd together due to dehydration, they can stick together ...
Sickle-cell versions of hemoglobin stick to themselves, stacking to form fibers that distort the shape of red blood cells carrying the protein. These sickle-shaped cells no longer flow smoothly through blood vessels, having a tendency to clog or degrade, causing the medical problems associated with this disease. [citation needed]
Many (15%) who live 40 years or longer develop Alzheimer's disease. [53] In those who reach 60 years of age, 50–70% have the disease. [9] Down syndrome regression disorder is a sudden regression with neuropsychiatric symptoms such as catatonia, possibly caused by an autoimmune disease. [54] It primarily appears in teenagers and younger adults ...
Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease of mainly the central nervous system that affects both the motor and non-motor systems of the body. The symptoms usually emerge slowly, and, as the disease progresses, non-motor symptoms become more common. Usual symptoms include tremors, slowness of movement ...
Sickle-cell anemia, which can cause blood cells to clump up and block blood vessels, can also lead to stroke. Stroke is the second leading cause of death in people under 20 with sickle-cell anemia. [52] Air pollution may also increase stroke risk. [53]
By way of analogy, the allele (a particular version of a gene) which causes sickle cell disease when two copies are present, also confers an adaptive advantage when one copy is present by providing resistance to malaria with non-symptomatic sickle cell trait—which is known as "heterozygote advantage". [96]
Dissociative identity disorder [1] [2]; Other names: Multiple personality disorder Split personality disorder: Specialty: Psychiatry, clinical psychology: Symptoms: At least two distinct and relatively enduring personality states, [3] recurrent episodes of dissociative amnesia, [3] inexplicable intrusions into consciousness (e.g., voices, intrusive thoughts, impulses, trauma-related beliefs ...
Michael Jackson 's Thriller, estimated to have sold 70 million copies worldwide, is the best-selling album ever. [4][5][6] Jackson also currently has the highest number of albums on the list with five, Celine Dion has four, while the Beatles, Pink Floyd, Madonna and Whitney Houston each have three. Groupings are based on different sales ...