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Sickle cell disease is a group of blood disorders inherited from both parents, causing abnormal red blood cells that can lead to pain, anemia, infections, and organ damage. Learn about the symptoms, diagnosis, treatment, and prevention of sickle cell disease and its subtypes.
Sickle cell trait is a condition where a person has one abnormal allele of the hemoglobin beta gene (genotype AS) and produces both normal and abnormal hemoglobin. It is associated with some resistance to malaria, but also rare complications such as sickle cell crisis, renal medullary carcinoma, and urinary tract infection.
SCDAA is a nonprofit organization that supports research, education and funding for sickle cell disease and related conditions. It has over 40 branches across the US and hosts events such as the National Sickle Cell Walk and the Sickle Cell Disease National Convention.
A study published in 2021 found that 50% of sickle cell patients reported having to wait at least two hours before their pain was treated, despite medical guidelines recommending such patients in ...
Fetal hemoglobin (HbF) is the main oxygen carrier protein in the human fetus, produced at around 6 weeks of pregnancy and gradually replaced by adult hemoglobin (HbA) after birth. Learn about its structure, genetics, function, diseases and treatment from this comprehensive article.
A 1949 paper by Pauling and colleagues that established sickle cell anemia as a genetic disease of hemoglobin structure and function. The paper introduced the concept of a molecular disease and influenced the development of molecular medicine and evolutionary theory.