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  2. Point mutation - Wikipedia

    en.wikipedia.org/wiki/Point_mutation

    Sickle-cell anemia is an autosomal recessive disorder that affects 1 in 500 African Americans, and is one of the most common blood disorders in the United States. [17] The single replacement of the sixth amino acid in the beta-globin, glutamic acid, with valine results in deformed red blood cells. These sickle-shaped cells cannot carry nearly ...

  3. Sickle Cell Anemia, a Molecular Disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_Cell_Anemia,_a...

    "Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood.

  4. Isosthenuria - Wikipedia

    en.wikipedia.org/wiki/Isosthenuria

    Isosthenuria may be seen in disease states as chronic kidney disease and acute kidney injury in which the kidneys lack the ability to concentrate or dilute the urine and so the initial filtrate of the blood remains unchanged despite the need to conserve or excrete water based on the body's hydration status.

  5. Iron-deficiency anemia - Wikipedia

    en.wikipedia.org/wiki/Iron-deficiency_anemia

    Iron-deficiency anemia is anemia caused by a lack of iron. [3] Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. [3] When onset is slow, symptoms are often vague such as feeling tired, weak, short of breath, or having decreased ability to exercise. [1]

  6. Hereditary elliptocytosis - Wikipedia

    en.wikipedia.org/wiki/Hereditary_elliptocytosis

    Hereditary elliptocytosis, also known as ovalocytosis, is an inherited blood disorder in which an abnormally large number of the person's red blood cells are elliptical rather than the typical biconcave disc shape.

  7. Vaso-occlusive crisis - Wikipedia

    en.wikipedia.org/wiki/Vaso-occlusive_crisis

    A vaso-occlusive crisis is a common painful complication of sickle cell anemia in adolescents and adults. [1] [2] It is a form of sickle cell crisis.Sickle cell anemia – most common in those of African, Hispanic, and Mediterranean origin – leads to sickle cell crisis when the circulation of blood vessels is obstructed by sickled red blood cells, causing ischemic injuries.

  8. Anemia - Wikipedia

    en.wikipedia.org/wiki/Anemia

    The types of anemia treated with drugs are iron-deficiency anemia, thalassemia, aplastic anemia, hemolytic anemia, sickle cell anemia, and pernicious anemia, the most important of them being deficiency and sickle cell anemia with together 60% of market share because of highest prevalence as well as higher treatment costs compared with other ...

  9. Ryan Clark (American football) - Wikipedia

    en.wikipedia.org/wiki/Ryan_Clark_(American_football)

    Clark is involved with sickle cell disease awareness, research, treatment and programming in Pittsburgh. In 2012, he announced the formation of Ryan Clark's Cure League to raise awareness about sickle cell trait and eventually find a cure.