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Sickle cell disease is a group of inherited blood disorders that affect the shape and function of red blood cells. It can cause pain, anemia, infections, stroke, and organ damage. Learn about the genetics, diagnosis, and management of sickle cell disease.
Sickle cell trait is a condition where a person has one abnormal allele of the hemoglobin beta gene (genotype AS) and produces both normal and abnormal hemoglobin. It is associated with some resistance to malaria, but also rare complications such as sickle cell crisis, renal medullary carcinoma, and urinary tract infection.
Learn about human traits that are influenced by Mendelian inheritance, such as albinism, sickle-cell disease, and lactase persistence. Find out the patterns of inheritance, examples, and non-Mendelian traits.
Pfizer bought Oxbryta, also known as voxelotor, as part of its $5.4 billion buyout of Global Blood Therapeutics in 2022. Pfizer is also discontinuing all studies and access programs related to the ...
Learn how inherited changes in DNA increase resistance to malaria and result in blood disorders. Find out how malaria exerts evolutionary pressure on human genome and how it affects red blood cells.
Learn about the genetic phenomenon of heterozygote advantage, where the heterozygous genotype has higher fitness than either homozygote. Find out how it works, why it occurs, and what examples exist in nature and humans.
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