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  2. Tionne Watkins - Wikipedia

    en.wikipedia.org/wiki/Tionne_Watkins

    Tionne Watkins. Tionne Tenese Watkins (born April 26, 1970), [2] better known by her stage name T-Boz, is an American singer. Born in Des Moines, Iowa, Watkins rose to fame in the early 1990s as a member of the girl-group TLC. She has won four Grammy Awards for her work with TLC.

  3. Sickle-cell anemia - Wikipedia

    en.wikipedia.org/?title=Sickle-cell_anemia&...

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  4. Thalassemia - Wikipedia

    en.wikipedia.org/wiki/Thalassemia

    16,800 (2015) [6] Thalassemias are inherited blood disorders that result in abnormal hemoglobin. [7] Symptoms depend on the type of thalassemia and can vary from none to severe. [1] Often there is mild to severe anemia (low red blood cells or hemoglobin) as thalassemia can affect the production of red blood cells and also affect how long the ...

  5. Genetic disorder - Wikipedia

    en.wikipedia.org/wiki/Genetic_disorder

    Genetic disorder. A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality. Although polygenic disorders are the most common, the term is mostly used when discussing disorders with a single ...

  6. Sickle cell anemia - Wikipedia

    en.wikipedia.org/?title=Sickle_cell_anemia&...

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  7. Heterozygote advantage - Wikipedia

    en.wikipedia.org/wiki/Heterozygote_advantage

    Sickle-cell anemia. Sickle-cell anemia (SCA) is a genetic disorder caused by the presence of two incompletely recessive alleles. When a sufferer's red blood cells are exposed to low-oxygen conditions, the cells lose their healthy round shape and become sickle-shaped. This deformation of the cells can cause them to become lodged in capillaries ...

  8. Point mutation - Wikipedia

    en.wikipedia.org/wiki/Point_mutation

    Sickle-cell anemia is an autosomal recessive disorder that affects 1 in 500 African Americans, and is one of the most common blood disorders in the United States. The single replacement of the sixth amino acid in the beta-globin, glutamic acid, with valine results in deformed red blood cells. These sickle-shaped cells cannot carry nearly as ...

  9. Sickle cell nephropathy - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_nephropathy

    Specialty. Nephrology. Sickle cell nephropathy is a type of nephropathy associated with sickle cell disease which causes kidney complications as a result of sickling of red blood cells in the small blood vessels. The hypertonic and relatively hypoxic environment of the renal medulla, coupled with the slow blood flow in the vasa recta, favors ...