Ads
related to: sickle cell genes- Learn About Treatment
Learn About the Treatment Journey.
Watch the Video to Learn More.
- Patient FAQs
Get Answers to Common Questions.
Understand the Potential Risks.
- View Discussion Guides
Download Treatment Brochures,
Discussion Guides, and More.
- Safety and Side Effects
Review the Important Safety
Information & Side Effects.
- Patient Information
View Important Patient Information.
Understand the Treatment.
- Find an ATC
Find an Authorized Treatment Center
On the Official Patient Website.
- Learn About Treatment
Search results
Results From The WOW.Com Content Network
To balance this loss of sickle-cell genes, a mutation rate of 1:10.2 per gene per generation would be necessary. This is about 1000 times greater than mutation rates measured in Drosophila and other organisms and much higher than recorded for the sickle-cell locus in Africans. [70]
"Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood.
A well-established case of heterozygote advantage is that of the gene involved in sickle cell anaemia. Often, the advantages and disadvantages conveyed are rather complicated, because more than one gene may influence a given trait or morph.
This would be similar to the hemoglobin allele which is responsible for sickle-cell disease, but solely in people with two copies; those with just one copy of the allele have a sickle cell trait and gain partial immunity to malaria as a result. This effect is called heterozygote advantage. [27]
Overdominance is a phenomenon in genetics where the phenotype of the heterozygote lies outside the phenotypical range of both homozygous parents. Overdominance can also be described as heterozygote advantage regulated by a single genomic locus, wherein heterozygous individuals have a higher fitness than homozygous individuals.
Strength of natural selection plot as a function of age. The antagonistic pleiotropy hypothesis (APT) is a theory in evolutionary biology that suggests certain genes may confer beneficial effects early in an organism's life, enhancing reproductive success, while also causing detrimental effects later in life, contributing to the aging process.
Ad
related to: sickle cell genes