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All the major organs are affected by sickle cell disease. The liver, heart, kidneys, gallbladder, eyes, bones, and joints also can suffer damage from the abnormal functions of the sickle cells, and their inability to flow through the small blood vessels correctly.
Sickle cell anemia affects about 72,000 people in the United States. Most Americans who have sickle cell anemia are of African descent. The disease also affects Americans from the Caribbean, Central America, and parts of South America, Turkey, Greece, Italy, the Middle East and East India.
A well-established case of heterozygote advantage is that of the gene involved in sickle cell anaemia. Often, the advantages and disadvantages conveyed are rather complicated, because more than one gene may influence a given trait or morph .
A sickle cell health crisis can escalate into life-threatening complications, but patients still struggle to get seen quickly in emergency rooms and also to get pain medicine.
With the help of Professor Marcus Pembrey, Anionwu taught a course at University College London for National Health Service (NHS) staff members who worked with communities affected or at risk of sickle-cell disease, cystic fibrosis, Tay–Sachs disease and thalassaemia.
Sickle cell anemia – most common in those of African, Hispanic, and Mediterranean origin – leads to sickle cell crisis when the circulation of blood vessels is obstructed by sickled red blood cells, causing ischemic injuries.
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