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Sickle cell test. A urologist might request this test for men with a higher risk of sickle cell disease. Duplex ultrasound. Sometimes called ultrasonography, this can measure blood flow in your ...
In 2023, the first drug making use of CRISPR gene editing, Casgevy, was approved for use in the United Kingdom to cure sickle-cell disease and beta thalassemia. [ 13 ] [ 14 ] Casgevy was approved for use in the United States on December 8, 2023, by the Food and Drug Administration .
By way of analogy, the allele (a particular version of a gene) which causes sickle cell disease when two copies are present, also confers an adaptive advantage when one copy is present by providing resistance to malaria with non-symptomatic sickle cell trait—which is known as "heterozygote advantage". [96]
Sickle-cell anemia, which can cause blood cells to clump up and block blood vessels, can also lead to stroke. Stroke is the second leading cause of death in people under 20 with sickle-cell anemia. [52] Air pollution may also increase stroke risk. [53]
Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease of mainly the central nervous system that affects both the motor and non-motor systems of the body. The symptoms usually emerge slowly, and, as the disease progresses, non-motor symptoms become more common. Usual symptoms include tremors, slowness of movement ...
The disease affects how oxygen is delivered to the red blood cells and is often diagnosed at a young age, discovered through a diagnosis of anemia. In a 2019 study on racial discrimination and dental health in the U.S. the authors found that the "emotional impact of racial discrimination" results in fewer visits to a dentist. [49]
It may be caused by an underlying disease, such as sickle cell anemia, cystic fibrosis, rheumatoid arthritis. Cancer or functional disorders such as migraines, fibromyalgia, and complex regional pain could also cause chronic pain in children. [95]
Hematologic diseases: chronic hemolytic anemia (including sickle cell disease) Systemic diseases: sarcoidosis, pulmonary Langerhans cell histiocytosis: lymphangioleiomyomatosis, neurofibromatosis, vasculitis; Metabolic disorders: glycogen storage disease, Gaucher disease, thyroid diseases