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Sickle cell disease is a group of blood disorders inherited from both parents, causing abnormal red blood cells that can lead to pain, anemia, infections, and organ damage. Learn about the symptoms, diagnosis, treatment, and prevention of sickle cell disease and its subtypes.
A 1949 paper by Pauling and colleagues that established sickle cell anemia as a genetic disease of hemoglobin structure and function. The paper introduced the concept of a molecular disease and influenced the development of molecular medicine and evolutionary theory.
Red cell alloimmunisation is common in people with sickle cell disease who receive transfusions in Europe and North America. This is because there are ethnic differences in the frequencies of blood group antigens. Blood donors are usually Caucasian whereas the blood transfusion recipients usually have an African or Afro-Caribbean ancestry.
Sickle cell trait is a condition where a person has one abnormal allele of the hemoglobin beta gene (genotype AS) and produces both normal and abnormal hemoglobin. It is associated with some resistance to malaria, but also rare complications such as sickle cell crisis, renal medullary carcinoma, and urinary tract infection.
SCDAA is a nonprofit organization that supports research, education and funding for sickle cell disease and related conditions. It has over 40 branches across the US and hosts events such as the National Sickle Cell Walk and the Sickle Cell Disease National Convention.
Vaso-occlusive crisis (VOC) is a complication of sickle cell anemia, a genetic disorder that affects red blood cells. VOC causes pain, organ damage, and sometimes death. Learn about the symptoms, diagnosis, and treatment of VOC.
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