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Sickle-cell disease was the genetic disorder to be linked to a mutation of a specific protein. Pauling introduced his fundamentally important concept of sickle cell anemia as a genetically transmitted molecular disease. [20] This vein (4) shows the interaction between the malaria sporozoites (6) with sickle cells (3) and regular cells (1).
The sickle cell trait provides a survival advantage against malaria fatality over people with normal hemoglobin in regions where malaria is endemic. The trait is known to cause significantly fewer deaths due to malaria, especially when Plasmodium falciparum is the causative organism.
The Pacific Ocean is the largest and deepest of Earth's five oceanic divisions.It extends from the Arctic Ocean in the north to the Southern Ocean (or, depending on definition, to Antarctica) in the south, and is bounded by the continents of Asia and Australia in the west and the Americas in the east.
The Waldseemüller map or Universalis Cosmographia ("Universal Cosmography") is a printed wall map of the world by German cartographer Martin Waldseemüller, originally published in April 1507. It is known as the first map to use the name " America ".
Most water in Earth's atmosphere and crust comes from saline seawater, while fresh water accounts for nearly 1% of the total. The vast bulk of the water on Earth is saline or salt water, with an average salinity of 35‰ (or 3.5%, roughly equivalent to 34 grams of salts in 1 kg of seawater), though this varies slightly according to the amount of runoff received from surrounding land.
A sickle, bagging hook, reaping-hook or grasshook is a single-handed agricultural tool designed with variously curved blades and typically used for harvesting or reaping grain crops, or cutting succulent forage chiefly for feeding livestock.
Early world maps cover depictions of the world from the Iron Age to the Age of Discovery and the emergence of modern geography during the early modern period.Old maps provide information about places that were known in past times, as well as the philosophical and cultural basis of the map, which were often much different from modern cartography.
The country of Brazil occupies roughly half of South America, bordering the Atlantic Ocean.Brazil covers a total area of 8,514,215 km 2 (3,287,357 sq mi) which includes 8,456,510 km 2 (3,265,080 sq mi) of land and 55,455 km 2 (21,411 sq mi) of water.