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Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. The most common type is known as sickle cell anemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells.
Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous), but does not display the severe symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous).
The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell anemia. This condition commonly manifests with a new opacification of the lung(s) on a chest x-ray.
Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood.
As a child, Watkins was diagnosed with sickle cell anemia. Since the age of seven, she has been in and out of the hospital due to the painful condition. T-Boz opened up to the public about the disease in 1996; she later became one of the spokespersons for Sickle Cell Disease Association of America.
Schistocytes on the peripheral blood smear is a characteristic feature of microangiopathic hemolytic anemia (MAHA). The causes of MAHA can be disseminated intravascular coagulation , thrombotic thrombocytopenic purpura , hemolytic-uremic syndrome , HELLP syndrome , malfunctioning cardiac valves etc.
The Sickle Cell Disease Association of America, Inc. (SCDAA) is a nonprofit organization with the sole purpose of supporting research, education and funding of individuals, families those who are impacted by sickle cell disease.
Sickle cell retinopathy can be defined as retinal changes due to blood vessel damage in the eye of a person with a background of sickle cell disease. It can likely progress to loss of vision in late stages due to vitreous hemorrhage or retinal detachment . [1]
As a medical resident at Hopkins in 1922 Mason gave the disease sickle cell anemia its name. Internist. When motion picture director Frank Capra fell ill with a mysterious fever after completing It Happened One Night, Columbia Pictures chief Harry Cohn called in Mason to diagnose and treat Capra's illness.
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