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  2. Lovotibeglogene autotemcel - Wikipedia

    en.wikipedia.org/wiki/Lovotibeglogene_autotemcel

    Lovotibeglogene autotemcel is indicated for the treatment of people aged twelve years of age and older with sickle cell disease and a history of vaso-occlusive events. [1] [3] The recipient's blood stem cells are genetically modified to produce HbA (T87Q), a gene-therapy derived hemoglobin A, which is similar to the normal adult hemoglobin ...

  3. FDA approves cure for sickle cell disease, the first ... - AOL

    www.aol.com/news/fda-approves-cure-sickle-cell...

    Berkeley Lovelace Jr. and Marina Kopf. December 8, 2023 at 1:19 PM. The Food and Drug Administration on Friday approved a powerful treatment for sickle cell disease, a devastating illness...

  4. Sickle cell disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_disease

    114,800 (2015) [8] Sickle cell disease ( SCD ), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. [2] The most common type is known as sickle cell anemia. [2] It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2]

  5. FDA approves gene therapy for sickle cell disease: 'One ... - AOL

    www.aol.com/fda-approves-gene-therapy-sickle...

    Federal officials Friday approved two gene therapy treatments for sickle cell disease, welcome news for thousands with the inherited blood disorder that causes terrible pain crises and...

  6. Döhle bodies - Wikipedia

    en.wikipedia.org/wiki/Döhle_bodies

    Döhle bodies. Döhle bodies are light blue-gray, oval, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils. They measure 1–3 μm in diameter. Not much is known about their formation, but they are thought to be remnants of the rough endoplasmic reticulum. [citation needed] They are named after German ...

  7. A new cure for sickle cell disease may be coming. FDA ... - AOL

    www.aol.com/cure-sickle-cell-disease-may...

    Scientists believe being a carrier of the sickle cell trait helps protect against severe malaria. Current treatments include medications and blood transfusions.

  8. Gene therapy - Wikipedia

    en.wikipedia.org/wiki/Gene_therapy

    Gene therapy is a medical technology that aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells. [1] [2] [3] The first attempt at modifying human DNA was performed in 1980, by Martin Cline, but the first successful nuclear gene transfer in humans, approved ...

  9. FDA considers first CRISPR gene editing treatment that may ...

    www.aol.com/fda-considers-first-crispr-gene...

    The independent committee is helping the FDA think through how it should evaluate a treatment called exa-cel that could potentially cure people of sickle cell disease, a painful and deadly...

  10. Hemoglobin Lepore syndrome - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome

    Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease (HbS) that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three variants described in association with HbS.

  11. New sickle cell treatment sparks feelings of hope and some ...

    www.aol.com/news/sickle-cell-treatment-sparks...

    While sickle cell disease is most known for causing severe pain, patients can experience stroke, heart disease, organ damage and a dangerous condition called acute chest syndrome caused by ...