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Sickle-cell trait, the heterozygous form of sickle-cell disease, presents with a normal hematological picture but is associated with hyposthenuria. See also. ...
Acute chest syndrome. The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell anemia. This condition commonly manifests with a new opacification of the lung (s) on a chest x-ray. [1]
An example of this is sickle cell anaemia, which results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. Possessors of the deleterious allele have much lower life expectancies, with homozygotes rarely reaching 50 years of age. However, this allele also enhances resistance to malaria. Thus, in regions where ...
Sickle-cell disease was the genetic disorder to be linked to a mutation of a specific protein. Pauling introduced his fundamentally important concept of sickle cell anemia as a genetically transmitted molecular disease. This vein (4) shows the interaction between the malaria sporozoites (6) with sickle cells (3) and regular cells (1).
This hypothesis is commonly invoked to explain the persistence of some alleles (most famously the Sickle cell trait allele) that are harmful in homozygotes. In normal circumstances, such harmful alleles would be removed from a population through the process of natural selection.
Hemoglobin electrophoresis is a blood test that can detect different types of hemoglobin. The test can detect hemoglobin S, the form associated with sickle cell disease, as well as other abnormal types of hemoglobin, such as hemoglobin C. It can also be used to investigate thalassemias, which are disorders caused by defective hemoglobin production.
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