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Sickle cell disease ( SCD ), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. [2] The most common type is known as sickle cell anemia. [2] It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2] This leads to a rigid, sickle -like shape under ...
Known for. Sickle cell disease. Scientific career. Institutions. National Institutes of Health. King's College London. Swee Lay Thein FRCP FMedSci is a Malaysian haematologist and physician-scientist who is Senior Investigator at the National Institutes of Health. She works on the pathophysiology of haemoglobin disorders including sickle cell ...
Sickle cell retinopathy. Sickle cell retinopathy can be defined as retinal changes due to blood vessel damage in the eye of a person with a background of sickle cell disease. It can likely progress to loss of vision in late stages due to vitreous hemorrhage or retinal detachment. [1] Sickle cell disease is a structural red blood cell disorder ...
The Sickle Cell Disease Association of America, Inc. originated in Racine, Wisconsin. Representatives from 15 different community-based sickle cell organizations came together at Wingspread, a community center, as guest of the Johnson Foundation. There was a common belief that there was a need for national attention to sickle cell disease.
Hematology. Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous ), but does not display the severe symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous ). Those who are heterozygous for the sickle cell allele produce ...
Clarice D. Reid (born 1931) is an American pediatrician born in Birmingham, Alabama, who led the National Sickle Cell Disease Program at the U.S. National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health. [2] She went on to become the Director of Division of Blood Diseases and Resources at NHLBI.
University of California, San Francisco. Scientific career. Fields. Hematology. Institutions. National Institutes of Health. Courtney D. Fitzhugh is an American hematologist-oncologist and scientist. She is a clinical researcher and head of the laboratory of early sickle cell mortality prevention at the National Heart, Lung, and Blood Institute .
Sickle Cell Anemia, a Molecular Disease. " Sickle Cell Anemia, a Molecular Disease " is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood.