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  2. Anthony Clifford Allison - Wikipedia

    en.wikipedia.org/wiki/Anthony_Clifford_Allison

    At the time it was a scientific puzzle that the disease was prevalent even though it killed people before they reached puberty, before they can have children to pass on the lethal gene. [4] He found that the prevalence of sickle-cell trait (heterozygous condition) among people inhabiting coastal areas was higher than 20%. [8]

  3. Chromosome 11 - Wikipedia

    en.wikipedia.org/wiki/Chromosome_11

    At about 21.5 genes per megabase, chromosome 11 is one of the most gene-rich, and disease-rich, chromosomes in the human genome. More than 40% of the 856 olfactory receptor genes in the human genome are located in 28 single-gene and multi-gene clusters along the chromosome.

  4. Health in Sudan - Wikipedia

    en.wikipedia.org/wiki/Health_in_Sudan

    In Sudan, sickle cell disease was first reported in 1926 by Archibald. [23] The disease is considered one of the major types of anemia, especially in Western Sudan where the sickle cell gene is frequent [24] Sickle cell disease is the major haemoglobinopathy seen in Khartoum, the capital of Sudan. This may be attributed to the migration of ...

  5. Hemoglobin D-Punjab - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_D-Punjab

    1. Tyagi S, Marwaha N, Parmar V, Basu S. Sickle cell hemoglobin-D Punjab disease (Compound Heterozygous state). Ind J Hematol Blood Transf 2000;18:31-2. 2. Zeng YT, Huang SZ, Ren ZR, Li HJ (1989). "Identification of Hb D-Punjab gene: application of DNA amplification in the study of abnormal hemoglobins". Am. J. Hum. Genet. 44 (6): 886–9. PMC ...

  6. Human genetic resistance to malaria - Wikipedia

    en.wikipedia.org/wiki/Human_genetic_resistance...

    In the Baamba population living in the Semliki Forest region in Western Uganda the sickle-cell heterozygote (AS) frequency is 40%, which means that the frequency of the sickle-cell gene is 0.255 and 6.5% of children born are SS homozygotes.

  7. Hemoglobin Lepore syndrome - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome

    Hemoglobin Lepore syndrome is typically an asymptomatic hemoglobinopathy, which is caused by an autosomal recessive genetic mutation.The Hb Lepore variant, consisting of two normal alpha globin chains (HBA) and two delta-beta globin fusion chains which occurs due to a "crossover" between the delta (HBD) and beta globin (HBB) gene loci during meiosis and was first identified in the Lepore ...

  8. Verne Mason - Wikipedia

    en.wikipedia.org/wiki/Verne_Mason

    Born at Wapello, Iowa, in 1889, Mason received a B.S. from University of California, Berkeley, in 1911, and an M.D. from Johns Hopkins University in 1915. As a medical resident at Hopkins in 1922 Mason gave the disease sickle cell anemia its name.

  9. Balancing selection - Wikipedia

    en.wikipedia.org/wiki/Balancing_selection

    A well-studied case is that of sickle cell anemia in humans, a hereditary disease that damages red blood cells. Sickle cell anemia is caused by the inheritance of an allele (HgbS) of the hemoglobin gene from both parents. In such individuals, the hemoglobin in red blood cells is extremely sensitive to oxygen deprivation, which results in ...

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