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  2. Hemoglobin C - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_C

    Hemoglobin C (abbreviated as HbC) is an abnormal hemoglobin in which glutamic acid residue at the 6th position of the β-globin chain is replaced with a lysine residue due to a point mutation in the HBB gene. [1] People with one copy of the gene for hemoglobin C do not experience symptoms, but can pass the abnormal gene on to their children.

  3. Sickle cell nephropathy - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_nephropathy

    Sickle cell nephropathy is a type of nephropathy associated with sickle cell disease which causes kidney complications as a result of sickling of red blood cells in the small blood vessels. The hypertonic and relatively hypoxic environment of the renal medulla, coupled with the slow blood flow in the vasa recta, favors sickling of red blood ...

  4. Sickle cell-beta thalassemia - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell-beta_thalassemia

    Sickle cell-beta thalassemia is caused by inheritance of a sickle cell allele from one parent and a beta thalassemia allele from the other. Mutations. A sickle allele is always the same mutation of the beta-globin gene (glutamic acid to valine at amino acid six). In contrast, beta-thalassemia alleles can be created by many different mutations ...

  5. Human genetic resistance to malaria - Wikipedia

    en.wikipedia.org/wiki/Human_genetic_resistance...

    Sickle-cell disease was the genetic disorder to be linked to a mutation of a specific protein. Pauling introduced his fundamentally important concept of sickle cell anemia as a genetically transmitted molecular disease. This vein (4) shows the interaction between the malaria sporozoites (6) with sickle cells (3) and regular cells (1).

  6. Pleiotropy - Wikipedia

    en.wikipedia.org/wiki/Pleiotropy

    Photomicrograph of normal-shaped and sickle-shape red blood cells from a patient with sickle cell disease. Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal flexible, round shape. It is caused by a change in one nucleotide, a point mutation in the HBB gene.

  7. Hemoglobin Lepore syndrome - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome

    Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease (HbS) that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three variants described in association with HbS.

  8. Mexico - Wikipedia

    en.wikipedia.org/wiki/Mexico

    Mexico, [a] [b] officially the United Mexican States, [c] is a country in the southern portion of North America. Covering 1,972,550 km 2 (761,610 sq mi), [11] it is the world's 13th largest country by area; with a population of almost 130 million, it is the 10th most populous country and has the most Spanish speakers in the world. [12] Mexico ...

  9. Transfusion therapy (Sickle-cell disease) - Wikipedia

    en.wikipedia.org/wiki/Transfusion_therapy...

    Transfusion therapy for sickle-cell disease entails the use of red blood cell transfusions in the management of acute cases of sickle cell disease and as a prophylaxis to prevent complications by decreasing the number of red blood cells (RBC) that can sickle by adding normal red blood cells. [citation needed]

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