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Sickle cell disease is a group of blood disorders inherited from both parents, causing abnormal red blood cells that can lead to pain, anemia, infections, and organ damage. Learn about the symptoms, diagnosis, treatment, and prevention of sickle cell disease and its subtypes.
Sickle cell trait is a condition where a person has one abnormal allele of the hemoglobin beta gene (genotype AS) and produces both normal and abnormal hemoglobin. It is associated with some resistance to malaria, but also rare complications such as sickle cell crisis, renal medullary carcinoma, and urinary tract infection.
Through experimentation, she determined that if infants drank a glass of water once a day before age five, the increased blood volume reduced their chances of having a sickle-cell crisis, a condition in which the flow of damaged red blood cells is impeded, causing painful clogging of blood vessels.
Sickle cell disease, often called sickle cell anemia, which is its most serious form, is caused by a genetic disorder that alters the ability of red blood cells to deliver oxygen to every part of ...
James B. Herrick was an American physician and professor who described sickle-cell disease and myocardial infarction. He taught and practiced in Chicago, received several honorary degrees and awards, and was a Chaucer scholar.
SCDAA is a nonprofit organization that supports research, education and funding for sickle cell disease and related conditions. It has over 40 branches across the US and hosts events such as the National Sickle Cell Walk and the Sickle Cell Disease National Convention.
Red cell alloimmunisation is common in people with sickle cell disease who receive transfusions in Europe and North America. This is because there are ethnic differences in the frequencies of blood group antigens. Blood donors are usually Caucasian whereas the blood transfusion recipients usually have an African or Afro-Caribbean ancestry.
In collaboration with Linus Pauling, Itano used electrophoresis to demonstrate the difference between normal hemoglobin and sickle cell hemoglobin; their 1949 paper "Sickle Cell Anemia, a Molecular Disease" (coauthored also with S. J. Singer and Ibert C. Wells) [2] was a landmark in both molecular medicine and protein electrophoresis, though ...
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