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Sickle cell disease ( SCD ), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. [2] The most common type is known as sickle cell anemia. [2] It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2] This leads to a rigid, sickle -like shape under ...
NHM envisages achievement of universal access to equitable, affordable and quality health care services that are accountable and responsive to the needs of the people. History [ edit ] The National Rural Health Mission (NRHM), now under National Health Mission [1] is an initiative undertaken by the government of India to address the health ...
Presentation. The condition is asymptomatic, and is only noticed when screening for other hemoglobin disorders. [citation needed]Sickle cell disease. In persons with sickle cell disease, high levels of fetal hemoglobin as found in a newborn or as found abnormally in persons with hereditary persistence of fetal hemoglobin, the HbF causes the sickle cell disease to be less severe.
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A vaso-occlusive crisis is a common painful complication of sickle cell anemia in adolescents and adults. It is a form of sickle cell crisis. Sickle cell anemia – most common in those of African, Hispanic, and Mediterranean origin – leads to sickle cell crisis when the circulation of blood vessels is obstructed by sickled red blood cells, causing ischemic injuries. The most common ...
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A sickle allele is always the same mutation of the beta-globin gene (glutamic acid to valine at amino acid six). In contrast, beta-thalassemia alleles can be created by many different mutations including both deletion and non-deletion forms. [citation needed] Diagnosis. Patient may present with symptomatic anemia or with sickle crises.
Hydroxycarbamide. Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer. [2] [3] In sickle-cell disease it increases fetal hemoglobin and decreases the number of attacks. [2] It is taken by mouth.