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Sickle cell anemia is a classic example of the mixed benefit given by the staying power of pleiotropic genes, as the mutation to Hb-S provides the fitness benefit of malaria resistance to heterozygotes as sickle cell trait, while homozygotes have significantly lowered life expectancy—what is known as "heterozygote advantage". Since both of ...
In avian gastrulation, Koller's sickle is a local thickening of cells at the posterior edge of the upper layer of the area pellucida called the epiblast. Koller's sickle is crucial for avian development, due to its critical role in inducing the differentiation of various avian body parts. Koller's sickle induces primitive streak and Hensen's ...
For people living with the disease, a sickle cell crisis can happen at any time. When it does, their rigid, sickle-shaped red blood cells become stuck in their blood vessels, blocking flow and ...
University of California, San Francisco. Scientific career. Fields. Hematology. Institutions. National Institutes of Health. Courtney D. Fitzhugh is an American hematologist-oncologist and scientist. She is a clinical researcher and head of the laboratory of early sickle cell mortality prevention at the National Heart, Lung, and Blood Institute .
This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene. Interactions. BCAM has been shown to interact with Laminin, alpha 5. BCAM has also been shown to promote the metastasis of ovarian cancer.
Mark T. Gladwin. Mark T. Gladwin is an American physician-scientist and academic administrator serving as the dean of the University of Maryland School of Medicine since 2022. He is also the John Z. and Akiko K. Bowers Distinguished Professor and vice president for medical affairs of the University of Maryland, Baltimore. [1] [2]
Marshall Summar. Marshall L. Summar (born September 2, 1959 in Nashville, Tennessee) is an American physician, clinical geneticist and academic specializing in the field of genetics and rare disease. [1] [2] [3] He is board-certified in pediatrics, biochemical genetics and clinical genetics. [4] He is best known for his work in caring and ...
Sickle cell nephropathy is a type of nephropathy associated with sickle cell disease which causes kidney complications as a result of sickling of red blood cells in the small blood vessels. The hypertonic and relatively hypoxic environment of the renal medulla, coupled with the slow blood flow in the vasa recta, favors sickling of red blood ...