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Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease (HbS) that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three variants described in association with HbS.
In patients with sickle cell disease, red blood cells, which are usually disk-shaped, take on a crescent or sickle shape. This change can cause cells to clump together, leading to clots and ...
MedlinePlus. 002923. [ edit on Wikidata] An exchange transfusion is a blood transfusion in which the patient 's blood or components of it are exchanged with (replaced by) other blood or blood products. [1] The patient's blood is removed and replaced by donated blood or blood components. This exchange transfusion can be performed manually or ...
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells.
Otis Webb Brawley is an American physician and the Bloomberg Distinguished Professor of Oncology and Epidemiology at Johns Hopkins University. He served as Chief Medical and Scientific Officer and Executive Vice President of the American Cancer Society from July 2007 to November 2018. He is board certified in internal medicine and medical ...
Institutions. Johns Hopkins Medicine. Adrienne Williams Scott is an American ophthalmologist specialized in diabetic retinopathy, epiretinal membranes, and macular degeneration. She is chief of the Wilmer Eye Institute in Bel Air, Harford County, Maryland. She is an associate professor of ophthalmology at Johns Hopkins School of Medicine.
Pablo Rubinstein. Pablo Rubinstein is a pioneer (during the 1980s) in freezing of umbilical cord blood or placental blood cells for the use for unrelated donors to treat diseases like leukemia [1] and genetic diseases such as Tay–Sachs disease and sickle cell anemia. [2] He pioneered and established an international cord blood banking system ...
The National Human Genome Research Institute ( NHGRI) is an institute of the National Institutes of Health, located in Bethesda, Maryland. NHGRI began as the Office of Human Genome Research in The Office of the Director in 1988. This Office transitioned to the National Center for Human Genome Research ( NCHGR ), in 1989 to carry out the role of ...