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The COVID-19 pandemic in France has resulted in 38,997,490 confirmed cases of COVID-19 and 168,091 deaths. The virus was confirmed to have reached France on 24 January 2020, when the first COVID-19 case in both Europe and France was identified in Bordeaux. The first five confirmed cases were all individuals who had recently arrived from China.
Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. The most common type is known as sickle cell anemia . [2] It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells . [2]
The membrane (M) protein (previously called E1, sometimes also matrix protein [2]) is an integral membrane protein that is the most abundant of the four major structural proteins found in coronaviruses. [3] [4] [5] The M protein organizes the assembly of coronavirus virions through protein-protein interactions with other M protein molecules as ...
The earliest reports of a coronavirus infection in animals occurred in the late 1920s, when an acute respiratory infection of domesticated chickens emerged in North America. [15] Arthur Schalk and M.C. Hawn in 1931 made the first detailed report which described a new respiratory infection of chickens in North Dakota.
The nucleocapsid (N) protein is a protein that packages the positive-sense RNA genome of coronaviruses to form ribonucleoprotein structures enclosed within the viral capsid. [2] [3] The N protein is the most highly expressed of the four major coronavirus structural proteins. [2] In addition to its interactions with RNA, N forms protein-protein ...
Coronavirus lineage B.1.1.28 has originated four known lineages classified as variant of interest (VOI) or variant of concern (VOC): lineages P.1, P.2, P.3 and P.4. Lineage P.2 (B.1.1.28.2, Zeta variant), first detected in October 2020 in the state of Rio de Janeiro , Brazil, only shares one mutation of concern with P.1, which is the E484K. [26]
The spike protein is very large, often 1200 to 1400 amino acid residues long; [8] it is 1273 residues in SARS-CoV-2. [5] It is a single-pass transmembrane protein with a short C-terminal tail on the interior of the virus, a transmembrane helix, and a large N-terminal ectodomain exposed on the virus exterior. [5] [7]
SARS-related coronavirus is a member of the genus Betacoronavirus (group 2) and monotypic of the subgenus Sarbecovirus (subgroup B). [12] Sarbecoviruses, unlike embecoviruses or alphacoronaviruses, have only one papain-like proteinase (PLpro) instead of two in the open reading frame ORF1ab. [13] SARSr-CoV was determined to be an early split-off ...