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  2. COVID-19 pandemic in France - Wikipedia

    en.wikipedia.org/wiki/COVID-19_pandemic_in_France

    The COVID-19 pandemic in France has resulted in 38,997,490 confirmed cases of COVID-19 and 168,091 deaths. The virus was confirmed to have reached France on 24 January 2020, when the first COVID-19 case in both Europe and France was identified in Bordeaux. The first five confirmed cases were all individuals who had recently arrived from China.

  3. Sickle cell disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_disease

    Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. The most common type is known as sickle cell anemia . [2] It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells . [2]

  4. Coronavirus membrane protein - Wikipedia

    en.wikipedia.org/wiki/Coronavirus_membrane_protein

    The membrane (M) protein (previously called E1, sometimes also matrix protein [2]) is an integral membrane protein that is the most abundant of the four major structural proteins found in coronaviruses. [3] [4] [5] The M protein organizes the assembly of coronavirus virions through protein-protein interactions with other M protein molecules as ...

  5. Coronavirus - Wikipedia

    en.wikipedia.org/wiki/Coronavirus

    The earliest reports of a coronavirus infection in animals occurred in the late 1920s, when an acute respiratory infection of domesticated chickens emerged in North America. [15] Arthur Schalk and M.C. Hawn in 1931 made the first detailed report which described a new respiratory infection of chickens in North Dakota.

  6. Coronavirus nucleocapsid protein - Wikipedia

    en.wikipedia.org/wiki/Coronavirus_nucleocapsid...

    The nucleocapsid (N) protein is a protein that packages the positive-sense RNA genome of coronaviruses to form ribonucleoprotein structures enclosed within the viral capsid. [2] [3] The N protein is the most highly expressed of the four major coronavirus structural proteins. [2] In addition to its interactions with RNA, N forms protein-protein ...

  7. SARS-CoV-2 Gamma variant - Wikipedia

    en.wikipedia.org/wiki/SARS-CoV-2_Gamma_variant

    Coronavirus lineage B.1.1.28 has originated four known lineages classified as variant of interest (VOI) or variant of concern (VOC): lineages P.1, P.2, P.3 and P.4. Lineage P.2 (B.1.1.28.2, Zeta variant), first detected in October 2020 in the state of Rio de Janeiro , Brazil, only shares one mutation of concern with P.1, which is the E484K. [26]

  8. Coronavirus spike protein - Wikipedia

    en.wikipedia.org/wiki/Coronavirus_spike_protein

    The spike protein is very large, often 1200 to 1400 amino acid residues long; [8] it is 1273 residues in SARS-CoV-2. [5] It is a single-pass transmembrane protein with a short C-terminal tail on the interior of the virus, a transmembrane helix, and a large N-terminal ectodomain exposed on the virus exterior. [5] [7]

  9. SARS-related coronavirus - Wikipedia

    en.wikipedia.org/wiki/SARS-related_coronavirus

    SARS-related coronavirus is a member of the genus Betacoronavirus (group 2) and monotypic of the subgenus Sarbecovirus (subgroup B). [12] Sarbecoviruses, unlike embecoviruses or alphacoronaviruses, have only one papain-like proteinase (PLpro) instead of two in the open reading frame ORF1ab. [13] SARSr-CoV was determined to be an early split-off ...