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Sickle cell disease is a group of blood disorders inherited from both parents, causing abnormal red blood cells that can lead to pain, anemia, infections, and organ damage. Learn about the symptoms, diagnosis, treatment, and prevention of sickle cell disease and its subtypes.
Sickle cell trait is a condition where a person has one abnormal allele of the hemoglobin beta gene (genotype AS) and produces both normal and abnormal hemoglobin. It is associated with some resistance to malaria, but also rare complications such as sickle cell crisis, renal medullary carcinoma, and urinary tract infection.
Hemoglobin C is an abnormal hemoglobin caused by a point mutation in the HBB gene. People with one copy of the gene (trait) are carriers and do not have symptoms, while those with two copies (disease) may have mild anemia and gallstones. Hemoglobin C also confers partial resistance to malaria caused by Plasmodium falciparum.
The main symptoms of sickle cell disease are disruptive to people’s “quality of life and ability to just function as normal humans,” she said. Kayla Smith Owens on her 25th receiving ...
Acute chest syndrome is a pulmonary complication of sickle cell anemia that causes lung inflammation and hypoxemia. It can be triggered by infections and requires antibiotics, pain relief, blood transfusion, and sometimes exchange transfusion.
For people living with the disease, a sickle cell crisis can happen at any time. When it does, their rigid, sickle-shaped red blood cells become stuck in their blood vessels, blocking flow and ...
Hereditary stomatocytosis is a group of inherited conditions that affect the red blood cell and cause it to have a slit-like area of central pallor (stomatocyte). It can be overhydrated or dehydrated, and may be associated with hemolytic anemia, jaundice, gallstones and other symptoms.
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