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Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. The most common type is known as sickle cell anemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells.
Eye examination. Treatment. Medical, laser and surgery. Sickle cell retinopathy can be defined as retinal changes due to blood vessel damage in the eye of a person with a background of sickle cell disease. It can likely progress to loss of vision in late stages due to vitreous hemorrhage or retinal detachment. [1]
Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous), but does not display the severe symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous).
Clarice D. Reid. 1931 (age 92–93) Birmingham, Alabama. Alma mater. Talladega College. University of Cincinnati College of Medicine. Known for. Sickle Cell Disease. Oversaw the National Sickle Cell Disease Program at the National Heart, Lung, and Blood Institute for over 20 years.
United States. President. Beverley Francis-Gibson. Website. www.sicklecelldisease.org. The Sickle Cell Disease Association of America, Inc. ( SCDAA) is a nonprofit organization with the sole purpose of supporting research, education and funding of individuals, families those who are impacted by sickle cell disease .
Rodgers is a physician-scientist who studies diseases of bone marrow and is best known for his work on the molecular genetics of hemoglobinopathies and on developing a treatment for sickle cell anemia. He was a major contributor to the development of hydroxyurea therapy, which was approved by the FDA in 1998.
Known for. Sickle cell disease. Scientific career. Institutions. National Institutes of Health. King's College London. Swee Lay Thein FRCP FMedSci is a Malaysian haematologist and physician-scientist who is Senior Investigator at the National Institutes of Health. She works on the pathophysiology of haemoglobin disorders including sickle cell ...
Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood.
Sickle cell-beta thalassemia is caused by inheritance of a sickle cell allele from one parent and a beta thalassemia allele from the other. Mutations. A sickle allele is always the same mutation of the beta-globin gene (glutamic acid to valine at amino acid six). In contrast, beta-thalassemia alleles can be created by many different mutations ...
To determine the origins of the sickle cell disease mutation, Rotimi studied the genomes of 3,000 people. He identified that sickle cell emerged around 7,000 years ago in Africa. Rotimi joined the National Institutes of Health in 2007, where he became founding director of the Trans-NIH Center for Research on Genomics and Global Health.