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  2. Autosplenectomy - Wikipedia

    en.wikipedia.org/wiki/Autosplenectomy

    Autosplenectomy can occur in cases of sickle-cell disease where the misshapen cells block blood flow to the spleen, causing scarring and eventual atrophy of the organ. [2] Autosplenectomy is a rare condition that is linked to certain diseases but is not a common occurrence. It is also seen in systemic lupus erythematosus (SLE).

  3. Anthony Clifford Allison - Wikipedia

    en.wikipedia.org/wiki/Anthony_Clifford_Allison

    He found that the prevalence of sickle-cell trait (heterozygous condition) among people inhabiting coastal areas was higher than 20%. [8] At the time the highest record was 8% among African-Americans.) [ 10 ] He was posed with the question as to why such a deadly disease (in homozygous condition ) would be more prevalent in a localised area in ...

  4. James B. Herrick - Wikipedia

    en.wikipedia.org/wiki/James_B._Herrick

    James B Herrick: the discoverer of sickle cell anemia. His first case report received scant interest--only in the 1950s was the role of "moon-crescent" shape considered]. Läkartidningen (in Swedish).

  5. Sickle - Wikipedia

    en.wikipedia.org/wiki/Sickle

    A sickle, bagging hook, reaping-hook or grasshook is a single-handed agricultural tool designed with variously curved blades and typically used for harvesting or reaping grain crops, or cutting succulent forage chiefly for feeding livestock.

  6. Sickle Cell Anemia, a Molecular Disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_Cell_Anemia,_a...

    "Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood.

  7. Human genetic resistance to malaria - Wikipedia

    en.wikipedia.org/wiki/Human_genetic_resistance...

    Sickle-cell disease was the genetic disorder to be linked to a mutation of a specific protein. Pauling introduced his fundamentally important concept of sickle cell anemia as a genetically transmitted molecular disease. [20] This vein (4) shows the interaction between the malaria sporozoites (6) with sickle cells (3) and regular cells (1).

  8. Double "H" Ranch - Wikipedia

    en.wikipedia.org/wiki/Double_"H"_Ranch

    The Double H offers activities which essentially define childhood; carefree play, interaction with peers, the expression of creativity through arts, song and sports. Programs allow children with Cancer, Leukemia, Sickle-Cell Anemia, Hemophilia, HIV/AIDS and Neuromuscular impairments the chance to grow both physically and emotionally.

  9. Splenic sequestration crisis - Wikipedia

    en.wikipedia.org/wiki/Splenic_sequestration_crisis

    Splenic sequestration crisis is a life-threatening illness common in pediatric patients with homozygous sickle cell disease and beta thalassemia.Up to 30% of these children may develop splenic sequestration crisis with a mortality rate of up to 15%.