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Arizona (/ ˌ ær ɪ ˈ z oʊ n ə / ⓘ ARR-iz-OH-nə; Navajo: Hoozdo Hahoodzo [hoː˥z̥to˩ ha˩hoː˩tso˩]; [10] O'odham: Alĭ ṣonak [ˈaɭi̥ ˈʂɔnak]) [11] is a state in the Southwestern region of the United States, sharing the Four Corners region of the western United States with Colorado, New Mexico, and Utah.
Pennsylvania (/ ˌ p ɛ n s ɪ l ˈ v eɪ n i ə / ⓘ PEN-sil-VAY-nee-ə, lit. ' Penn's forest country '), officially the Commonwealth of Pennsylvania [b] (Pennsylvania Dutch: Pennsylvanie), [7] is a state spanning the Mid-Atlantic, Northeastern, Appalachian, and Great Lakes regions of the United States.
The intravenous dose causing 50% of opioid-naive experimental subjects to die (LD 50) is "3 mg/kg in rats, 1 mg/kg in cats, 14 mg/kg in dogs, and 0.03 mg/kg in monkeys." [ 96 ] The LD 50 in mice has been given as 6.9 mg/kg by intravenous administration, 17.5 mg/kg intraperitoneally, 27.8 mg/kg by oral administration. [ 97 ]
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