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Sickle cell trait is a condition where a person has one abnormal allele of the hemoglobin beta gene (genotype AS) and produces both normal and abnormal hemoglobin. It is associated with some resistance to malaria, but also rare complications such as sickle cell crisis, renal medullary carcinoma, and urinary tract infection.
Sickle cell disease is a group of blood disorders inherited from both parents, causing abnormal red blood cells that can lead to pain, anemia, infections, and organ damage. Learn about the symptoms, diagnosis, treatment, and prevention of sickle cell disease and its subtypes.
Exagamglogene autotemcel is a gene therapy for sickle cell disease and beta thalassemia, developed by Vertex Pharmaceuticals and CRISPR Therapeutics. It is the first CRISPR/Cas9 gene editing therapy approved by the US FDA and the UK MHRA.
Sickle cell nephropathy is a type of kidney disease associated with sickle cell disease which causes kidney complications as a result of sickling of red blood cells in the small blood vessels. The hypertonic and relatively hypoxic environment of the renal medulla , coupled with the slow blood flow in the vasa recta , favors sickling of red ...
A life-threatening illness in pediatric patients with sickle cell disease and beta thalassemia. It occurs when blood gets trapped in the spleen, causing severe anemia and shock.
Learn about the genetic phenomenon of heterozygote advantage, where the heterozygous genotype has higher fitness than either homozygote. Find out how it works, why it occurs, and what examples exist in nature and humans.
Hemoglobin C is an abnormal hemoglobin caused by a point mutation in the HBB gene. People with one copy of the gene (trait) are carriers and do not have symptoms, while those with two copies (disease) may have mild anemia and gallstones. Hemoglobin C also confers partial resistance to malaria caused by Plasmodium falciparum.
What is salmonella and why is it so dangerous? Salmonella is a group of bacteria that can cause foodborne illness. ... and it is particularly problematic for those who have sickle cell anemia. ...