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Autosomal dominant A 50/50 chance of inheritance. Sickle-cell disease is inherited in the autosomal recessive pattern. When both parents have sickle-cell trait (carrier), a child has a 25% chance of sickle-cell disease (red icon), 25% do not carry any sickle-cell alleles (blue icon), and 50% have the heterozygous (carrier) condition. [1]
In medical genetics, compound heterozygosity is the condition of having two or more heterogeneous recessive alleles at a particular locus that can cause genetic disease in a heterozygous state; that is, an organism is a compound heterozygote when it has two recessive alleles for the same gene, but with those two alleles being different from each other (for example, both alleles might be ...
Hereditary spherocytosis is the heritable hemolytic disorder, affecting 1 in 2,000 people of Northern European ancestry. [5] According to Harrison's Principles of Internal Medicine, the frequency is at least 1 in 5,000 within the United States of America. [6]
Hemoglobinopathy is the medical term for a group of inherited blood disorders involving the hemoglobin, the protein of red blood cells. [1] They are single-gene disorders and, in most cases, they are inherited as autosomal co-dominant traits.
"Selfish" is the second episode of the seventh season of the American medical drama House. It aired on Fox on September 27, 2010. House (Hugh Laurie) treats a patient with sickle cell trait, while dealing with the effects of his burgeoning relationship with Lisa Cuddy (Lisa Edelstein) on his work.
Clark is involved with sickle cell disease awareness, research, treatment and programming in Pittsburgh. In 2012, he announced the formation of Ryan Clark's Cure League to raise awareness about sickle cell trait and eventually find a cure. [40]
This hypothesis is commonly invoked to explain the persistence of some alleles (most famously the Sickle cell trait allele) that are harmful in homozygotes. In normal circumstances, such harmful alleles would be removed from a population through the process of natural selection.
In addition, there is sickle cell trait (HbAS) which is defined by having HbA and HbS. This makes the individual heterozygous for sickle cell. Of the world population, it is estimated that there are about 300 million individuals with the sickle cell trait and about 100 million of those are in sub-Saharan Africa. [18]