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Sickle cell nephropathy is a type of kidney disease associated with sickle cell disease which causes kidney complications as a result of sickling of red blood cells in the small blood vessels. The hypertonic and relatively hypoxic environment of the renal medulla , coupled with the slow blood flow in the vasa recta , favors sickling of red ...
Genetic studies on Arabs refers to the analyses of the genetics of ethnic Arab people in the Middle East and North Africa.Arabs are genetically diverse as a result of their intermarriage and mixing with indigenous people of the pre-Islamic Middle East and North Africa following the Arab and Islamic expansion.
She co-authored over 60 journal articles and book chapters, and over 80 conference articles and proceedings. She has researched and published in the genetics of some non-communicable diseases such as breast cancers, asthma, malaria and specifically the haemoglobinopathies of sickle cell disease and the thalassaemias and other genetic modifiers.
Photomicrograph of normal-shaped and sickle-shape red blood cells from a patient with sickle cell disease. Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal flexible, round shape. [29] It is caused by a change in one nucleotide, a point mutation [30] in the HBB gene.
Hemoglobin E/β-thalassemia is a severe disease, and it still has no universal cure. However, the mutation is amenable to genome editing at high efficiency in preclinical studies. [6] It affects more than a million people in the world. [7]
CHORI is the first research institute in North America to transplant and cure a child with alpha thalassemia major, [citation needed] is a leading center for the use of cord blood and bone marrow transplantation in children with sickle cell anemia and thalassemia, and offers the only not-for-profit Sibling Donor Cord Blood Program in the world. [4]
World map of Plasmodium falciparum endemicity in 2010 World map of Plasmodium vivax endemicity in 2010. The Malaria Atlas Project (MAP) is a nonprofit academic group led by Peter Gething, Kerry M Stokes Chair in Child Health, at the Telethon Kids Institute, Perth, Western Australia.
Lovotibeglogene autotemcel, sold under the brand name Lyfgenia, is a lentiviral gene therapy used for the treatment of sickle cell disease. [1] [3] [4] [5]The most common side effects include stomatitis (mouth sores of the lips, mouth, and throat), low levels of platelets, white blood cells, and red blood cells, and febrile neutropenia (fever and low white blood cell count), consistent with ...