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Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. The most common type is known as sickle cell anemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells.
Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous), but does not display the severe symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous).
Herrick studied and taught at various Chicago hospitals. His first discovery, in 1910, was that of sickle-shaped red blood cells on the blood film of a dental student from Grenada. His description of the student's disease was known for many years as Herrick's syndrome, and is now known as sickle-cell disease.
Sickle-cell disease and resistance to malaria. In 1949 Allison participated in a vocational Oxford University Expedition to Mount Kenya. He took up the task of collecting blood samples from Kenyans for analyses of blood groups and genetic markers such as for sickle-cell disease.
Sickle cell-beta thalassemia is caused by inheritance of a sickle cell allele from one parent and a beta thalassemia allele from the other. Mutations. A sickle allele is always the same mutation of the beta-globin gene (glutamic acid to valine at amino acid six). In contrast, beta-thalassemia alleles can be created by many different mutations ...
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Harvey Akio Itano (Japanese: ハーベイ・アキオ・イタノ, November 3, 1920 – May 8, 2010) was an American biochemist best known for his work on the molecular basis of sickle cell anemia and other diseases.
Victoria Gray was the first patient ever to be treated with the gene-editing tool CRISPR for sickle-cell disease. [1] This marked the initial indication that a cure is attainable for individuals born with sickle-cell disease and another severe blood disorder, beta-thalassemia .
Website. www .elizabethanionwu .co .uk. Dame Elizabeth Nneka Anionwu OM DBE FRCN (born Elizabeth Mary Furlong; 2 July 1947) is a British nurse, health care administrator, lecturer, and Emeritus Professor of Nursing at the University of West London . In 1979, Anionwu became the United Kingdom's first sickle-cell and thalassemia nurse specialist ...
Roland Boyd Scott (April 18, 1909 – December 10, 2002) was an American researcher, pediatrician and authority on sickle cell disease. [1] Scott authored a key paper in 1948 describing the incidence of sickle cell in infants that eventually led to the establishment of routine screening for newborns. [1] He established the Howard University ...
Transfusion therapy for sickle-cell disease entails the use of red blood cell transfusions in the management of acute cases of sickle cell disease and as a prophylaxis to prevent complications by decreasing the number of red blood cells (RBC) that can sickle by adding normal red blood cells.