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Sickle cell disease ( SCD ), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. [2] The most common type is known as sickle cell anemia. [2] It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2] This leads to a rigid, sickle -like shape under ...
Human genetic clusters tend to be organized by geographic ancestry, with divisions between clusters aligning largely with geographic barriers such as oceans or mountain ranges. [2] [3] Clustering studies have been applied to global populations, [4] as well as to population subsets like post-colonial North America.
Hematology. Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous ), but does not display the severe symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous ). Those who are heterozygous for the sickle cell allele produce ...
The only cure for the pain sickle cell disease can cause is a bone marrow transplant or gene therapies like the one commercially approved by the U.S. Food and Drug Administration in December. A 12 ...
The Atlantic Ocean is the second-largest of the world's five oceanic divisions, with an area of about 85,133,000 km 2 (32,870,000 sq mi). [2] It covers approximately 17% of Earth's surface and about 24% of its water surface area. During the Age of Discovery, it was known for separating the New World of the Americas ( North America and South ...
The Ptolemy world map is a map of the world known to Greco-Roman societies in the 2nd century. It is based on the description contained in Ptolemy 's book Geography, written c. 150. Based on an inscription in several of the earliest surviving manuscripts, it is traditionally credited to Agathodaemon of Alexandria .
Sickle cell-beta thalassemia is caused by inheritance of a sickle cell allele from one parent and a beta thalassemia allele from the other. Mutations. A sickle allele is always the same mutation of the beta-globin gene (glutamic acid to valine at amino acid six). In contrast, beta-thalassemia alleles can be created by many different mutations ...
Origin of the concept. Alfred Wegener c. 1924 –1930. World map of Pangaea created by Alfred Wegener to illustrate his concept. The name "Pangaea" is derived from Ancient Greek pan ( πᾶν, "all, entire, whole") and Gaia or Gaea ( Γαῖα, " Mother Earth, land"). [4] [9] The first to suggest that the continents were once joined and later ...
Detail of the map showing the names "Catigara" and "Mallaqua" where "was slain St. Thomas". The Waldseemüller map or Universalis Cosmographia ("Universal Cosmography ") is a printed wall map of the world by German cartographer Martin Waldseemüller, originally published in April 1507. It is known as the first map to use the name "America".
Anthony Clifford Allison (21 August 1925 – 20 February 2014) was a South African geneticist and medical scientist who made pioneering studies on the genetic resistance to malaria. [2] Clark completed his primary schooling in Kenya, completed his higher education in South Africa, and obtained a BSc in medical science from the University of the ...
