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Hematology. Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous), but does not display the severe symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous). Those who are heterozygous for the sickle cell allele produce both ...
In the United States, about one out of 365 African-American children and one in every 16,300 Hispanic-American children have sickle cell anaemia. [138] The life expectancy for men with SCD is approximately 42 years of age while women live approximately six years longer. [139] An additional 2 million are carriers of the sickle cell trait. [140]
In the 1970s, according to Public Health Reports, life expectancy for people with sickle cell disease was less than 20 years. ... thereby increasing the survival rate of individuals with this trait.
Sickle cell anemia is caused by the inheritance of an allele (HgbS) of the hemoglobin gene from both parents. In such individuals, the hemoglobin in red blood cells is extremely sensitive to oxygen deprivation, which results in shorter life expectancy.
By comparison, research earlier this year showed medical expenses for current sickle cell treatments, from birth to age 65, add up to about $1.6 million for women and $1.7 million for men.
This would be similar to the hemoglobin allele which is responsible for sickle-cell disease, but solely in people with two copies; those with just one copy of the allele have a sickle cell trait and gain partial immunity to malaria as a result. This effect is called heterozygote advantage. [27]
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