C3
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Official Full Name
complement component 3
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Overview
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. -
Synonyms
complement C3; Acylation Stimulating Protein Cleavage Product; ASP; C3 and PZP like alpha 2 macroglobulin domain containing protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3; CO3_HUMAN; Complement C3 precursor; Complement C3c alpha'' chain fragment 2; Complement Component 3; Complement factor 3; CPAMD 1; CPAMD1;
- Recombinant Proteins
- Native Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Bovine
- C. botulinum
- Cattle
- Chicken
- Clostridium botulinum D bacteriophage
- Cynomolgus
- Human
- Monkey
- Mouse
- Pig
- Rabbit
- Rat
- Swine
- C. botulinum
- Clostridium botulinum D bacteriophage
- E.coli
- HEK293
- HEK293T
- Human Plasma
- Human serum
- Human Serum
- Mammalian Cell
- Mammalian cells
- Normal cynomolgus serum from healthy animals of mixed gender
- Normal mouse serum from healthy animals of mixed gender
- Normal rabbit serum from healthy animals of mixed gender
- Normal rat serum from healthy animals of mixed gender
- Plasma
- Yeast
- C
- His
- Flag
- His (Fc)
- Avi
- His|GST
- His|T7
- SUMO
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Tag Free
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | C3-603H | Active Recombinant Human C3 | E.coli | N/A | ||
Human | C3-365H | Active Native Human C3 Protein | Human Serum | N/A | ||
Human | C3-01H | Active Recombinant Human C3 Protein | E.coli | N/A | ||
Human | C3-7631H | Recombinant Human C3 protein, His-tagged | E.coli | His | Glu1322~Cys1661 | |
Human | C3-558H | Recombinant Human C3 Protein, His/GST-tagged | E.coli | His/GST | Ser672~Arg748 | |
Human | C3-10522H | Recombinant Human C3, His-tagged | E.coli | His | C-term-350a.a. | |
Human | C3-7842H | Recombinant Human C3 protein, His-tagged | E.coli | His | Leu1000~Glu1326 | |
Human | C3-1149H | Recombinant Human C3 Protein, His-tagged | E.coli | His | ||
Human | C3-7H | Active Human C3 Reference Standard | N/A | |||
Human | C3-10H | Active Recombinant Human C3 protein, His-tagged | HEK293 | His | Ser 23 - Asn 1663 | |
Human | C3-1841H | Recombinant Human C3 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | C3-365HFL | Recombinant Full Length Human C3 Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | C3-8391H | Native Human C3 | Plasma | N/A | ||
Human | C3-012H | Native Human Complement C3c | Human serum | |||
Human | C3-3052H | Recombinant Human C3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | C3-1859H | Active Recombinant Human C3 protein, His-Avi-tagged, Biotinylated | HEK293 | His-Avi | Ser 23 - Asn 1663 | |
Human | C3-471H | Recombinant Human C3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | C3-2505H | Recombinant Human C3 protein(961-1040 aa), C-His-tagged | E.coli | C-His | 961-1040 aa | |
Human | C3-471H-B | Recombinant Human C3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | C3-194H | Native Human Complement C3c | Human Plasma | N/A | ||
Human | C3-2212H | Recombinant Human C3 Protein (Ser672-Arg748) | E.coli | Tag Free | Ser672-Arg748 | |
Human | C3-8092H | Native Human Plasma COMPLEMENT C (C3) | Human Plasma | N/A | ||
Mouse | C3-7843M | Recombinant Mouse C3 protein, His-tagged | E.coli | His | Glu1314~Asn1663 (Accession # P01027) | |
Mouse | C3-559M | Recombinant Mouse C3 Protein, His/GST-tagged | E.coli | His/GST | Ser671~Arg748 | |
Mouse | C3-7632M | Recombinant Mouse C3 protein, His-tagged | E.coli | His | Ala965-Arg1303 | |
Mouse | C3-732M | Recombinant Mouse C3 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Mouse | C3-05M | Native Mouse C3 Protein | Normal mouse serum from healthy animals of mixed gender | |||
Mouse | C3-1944M | Recombinant Mouse C3 protein, His-tagged | HEK293 | His | Ile 25 - Asn 1663 | |
Mouse | C3-4246M | Recombinant Mouse C3 protein, His-SUMO-tagged | E.coli | His-SUMO | 1321-1663aa | |
Mouse | C3-33M | Mouse C3 Reference Standard | N/A | |||
Rat | C3-7845R | Recombinant Rat C3 protein, His-tagged | E.coli | His | Asp966~Trp1313 (Accession # P01026) | |
Rat | C3-561R | Recombinant Rat C3 Protein, His/GST-tagged | E.coli | His/GST | Ser671~Arg748 | |
Rat | C3-1050R | Recombinant Rat C3 Protein | Mammalian Cell | His | ||
Rat | C3-708R | Recombinant Rat C3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | C3-5695R | Recombinant Rat C3 protein, His-tagged | Yeast | His | 671-746aa | |
Rat | C3-73R | Rat C3 Reference Standard | N/A | |||
Rat | C3-08R | Native Rat C3 Protein | Normal rat serum from healthy animals of mixed gender | |||
Rat | C3-708R-B | Recombinant Rat C3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Monkey | C3-02M | Native Monkey C3 Protein | Normal cynomolgus serum from healthy animals of mixed gender | |||
Rabbit | C3-01R | Native Rabbit C3 Protein | Normal rabbit serum from healthy animals of mixed gender | |||
Rabbit | C3-4324R | Recombinant Rabbit C3 Protein | Yeast | N/A | 77aa | |
Bovine | C3-4464B | Recombinant Bovine C3 protein, His-SUMO-tagged | E.coli | His-SUMO | 747-953aa | |
C. botulinum | C3-001C | Active Native C. botulinum C3 Enzyme | C. botulinum | N/A | ||
Cattle | C3-338C | Recombinant Cattle C3 Protein, His-tagged | E.coli | N-His | Gly448-Thr665 | |
Clostridium botulinum D bacteriophage | C3-147C | Active Native Botulinum C3 Enzyme | Clostridium botulinum D bacteriophage | N/A | ||
Cynomolgus | C3-114C | Active Recombinant Cynomolgus C3 protein, His-tagged | HEK293 | His | Thr 23 - Asn 1663 | |
Swine | C3-4325S | Recombinant Swine C3 Protein | Yeast | N/A | 77aa | |
Pig | C3-560P | Recombinant Pig C3 Protein, His/GST-tagged | E.coli | His/GST | Ser670~Leu742 | |
Pig | C3-7844P | Recombinant Pig C3 protein, His & T7-tagged | E.coli | His/T7 | Asp23~Thr300 (Accession# P01025) | |
Chicken | C3-6956C | Recombinant Chicken C3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- C3 Related Articles
- C3 Related Research Area
C3 involved in several pathways and played different roles in them. We selected most pathways C3 participated on our site, such as Phagosome, Complement and coagulation cascades, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Phagosome | HBL4;TUBA1L;CTSSB.2;TLR2;ATP6AP1B;ATP6V1F;HLA-G;RAB5AA;CD209C |
Complement and coagulation cascades | KNG1;Hc;CFD;KLKB1;C8B;C1R;F13A1;C1QB;TFPI |
Pertussis | CFL2;IL1B;SERPING1;CXCL5;MAPK12;MYD88;C1R;IRAK1;C1QC |
Legionellosis | TLR2;EEF1G;TNF;RELA;BNIP3;HSPA1A;MYD88;ITGB2L;SAR1A |
Leishmaniasis | MAPK13;HLA-DRB5;NCF2;TNF;TGFB3;STAT1;FOS;HLA-DOB;Itgam&Itgb2 |
Chagas disease (American trypanosomiasis) | GNAQ;C1QB;GNAO1;PLCB4;MAPK12;CD3E; CD3D;LOC100033925;MAPK11;GNAI1 |
Staphylococcus aureus infection | HLA-DMB;FCGR1;DSG1A;C1S;H2-AA;H2-AB1;C3AR1;HLA-DPA1;C1QA |
Tuberculosis | CALM1;LAMP1;IFNA4;FADD;NOS2;RHOA;HLA-DOA;TLR2;STAT1 |
Herpes simplex infection | IL1B;PVRL1;C3A.2;TLR2-1;SRSF7A;CASP8;TNFB;IRF9;HLA-A |
Viral carcinogenesis | GTF2A1L;KAT2A;MAPKAPK2;GTF2H2C_2;HLA-C;RBL1;HIST2H2BB;PIK3R3;PIK3CD |
Systemic lupus erythematosus | H2AFX;C8B;HIST1H2BP;C5;HIST1H4K;HIST1H2BI;GM14479;FCGR4;H2AFZ |
C3 has several biochemical functions, for example, C5L2 anaphylatoxin chemotactic receptor binding, cofactor binding, endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C3 itself. We selected most functions C3 had, and list some proteins which have the same functions with C3. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
C5L2 anaphylatoxin chemotactic receptor binding | |
cofactor binding | ACLYA;BIRC5;TKT;ASNS;LMO2;HACL1;DAO;PHYH;ME3 |
endopeptidase inhibitor activity | SERPIND1;A1i3;Cstb;LPA;Serpina1c;SPINT2;USP14;CST3;SERPINA1A |
lipid binding | SEC14L3;APOEA;NME4;CYTH4;PAQR5A;FER;PTGS2;C3;DBIL5 |
protein binding | UBE2W;MTTP;CRYAB;EIF2B3;EHD2;ZNHIT6;RNF14;CBLB;ZBTB24 |
receptor binding | LRP6;TNFSF15;INHA;HAND2;TNFSF9;ZAP70;CHRNA10;PECR;FZD1 |
C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of C3.
VSIG4; VSIG4; CD46; d3jib2_staau; IGM; VHL; ASF1B; TGM2; q99ib8-pro_0000045598; q99ib8-pro_0000045601; d-mannose; crlkekhc; IGHM
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, a variety of proteins that interact with C3 proteins, including complement receptors, regulatory proteins, inflammatory factors, etc., have been discovered, and they are jointly involved in the regulation and functional execution of C3 proteins.
C3 protein plays an important role in infectious diseases. It can play an anti-infection role by activating the complement system, directly killing pathogens or enhancing the ability of immune cells to destroy pathogens.
Research on C3 protein is going on. At present, it mainly focuses on the analysis of its function and regulatory mechanism, the identification of gene mutations associated with diseases, and the interaction with other complement proteins and immune cells, which provides a theoretical basis for the further development of diagnosis and treatment methods of related diseases.
C3 protein can be used as an aid in the diagnosis of certain immune-related diseases. Measuring the level of C3 protein in serum can reflect the activity of the immune system and the degree of inflammation.
Post-translational modifications of the C3 protein can affect its function. Phosphorylation, cleavage, methylation and other modifications can regulate the activity, stability and interaction ability of C3 proteins.
Yes, some C3 protein-related drug treatments are under development, including drugs that regulate the degree of C3 protein activation, drugs that inhibit the overactivation of C3 protein, etc.
Customer Reviews (3)
Write a reviewExpression efficiency is high. In our experiments, we found that the target protein can be synthesized quickly and effectively.
Activity was not significantly different from the native protein, as expected.
High purity, no obvious impurities.
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